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The integration of adverse outcome pathways and aggregate exposure pathways for food safety testing: pesticides as a case study

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The integration of adverse outcome pathways and aggregate exposure pathways for food safety testing: pesticides as a case studyChemical risk assessment is moving towards non animal approaches that rely on the mechanistic understanding of toxicity. In this respect, the adverse outcome pathway (AOP) framework is a promising tool to capture chemical agnostic mechanistic understanding of toxicological processes. AOPs link a molecular initiating event to a specific adverse outcome via a series of key events and key event relationships. Sharing common key features to the AOP

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